个人简介

陶震，博士，副教授，硕士生导师，毕业于美国奥本大学（Auburn University）渔业与联合水产养殖专业。现为浙江海洋大学水产学院水生动物健康实验室负责人。Journal of Aquatic Animal Health杂志副主编。长期担任Aquaculture、Microbial pathogenesis、Journal of Fish Disease、《水产科学》等学术期刊的审稿人。

联系方式：taozhen123@zjou.edu.cn

主要研究兴趣：应用基因组学、分子生物学及合成生物学等领域的研究方法，专注于对东海地区鱼类病原菌的毒力因子及其调控网络进行系统性解析，旨在揭示病原体在侵染过程中的分子机制，并在此基础上，创新性地研发鱼用疫苗及药物和病原快速检测技术，以提升水产养殖动物的健康管理和疾病预防能力。

主要研究项目

1.国家自然科学基金面上项目“VI型分泌系统介导杀香鱼假单胞菌季节性感染鱼类宿主的毒力作用及其调控机制研究”，42376108，2024.01-2027.12（主持）

2.浙江省自然科学基金一般项目“杀香鱼假单胞菌溶血素共调节蛋白对大黄鱼的致病作用及机制研究”，LQ16C190001，2016.12-2018.12（主持）

3.宁波市科技局自然科学基金项目“大黄鱼致病原香鱼假单胞菌胞外蛋白毒力及其温度调控机制研究”，2014A610180，2014.02-2016.01（主持）

4.舟山市科技局自然科学基金项目“杀香鱼假单胞菌新型减毒活构建及其免疫保护效应的实验研究”，2018C21024，2018.01-2020.12（主持）

5.国家自然科学基金/面上项目“多重环境因子影响下的紫菜黄斑病致病机理研究”，31772871，2018.01-2021.12（参与）

6.国家自然科学基金/面上项目“溶血素4-羟苯丙酮酸二加氧酶介导灿烂弧菌致病的分子机制及调控研究”，41676141，2017.01-2020.12（参与）

7.宁波市科技局/重大（重点）择优委托科技攻关项目“虎斑乌贼产业化养殖技术研究与示范”，2014C11001，2014.05-2019.12（参与）

主要研究论文（#为通讯作者；更新至2024年3月）

1.Zhang C,Tao Z^#, Ye H, Wang P, Jiang M, Benard K, Li W, Yan X^#. Development and validation of a CRISPR/Cas12a-based platform for rapid and sensitive detection of the large yellow croaker iridovirus. Aquaculture. 2024;584:740658.

2.Tao Z^#, Ye H, Zhang C, Zhou S, Wang K, Zhang M, Xie J, Munang'andu HM, Xu C, Wang P, Yan X^#. PvgAS: A novel two-component system that controls type III and type VI secretion systems and virulence in the fish pathogen Pseudomonas plecoglossicida. Aquaculture. 2024;578:740102.

3.Zhou S, Wang Y, Shu F,Tao Z, Xie X, Xie J, Ma R, Yin F^#. Functional insights of a two-component system sensor kinase GacS in a fish pathogen, Pseudomonas plecoglossicida. Aquaculture. 2023;562:738866.

4.Zhang Y, Huang Y, Ding H, Ma J, Tong X, Zhang Y,Tao Z^#, Wang Q^#. A sigma(E)-mediated temperature gauge orchestrates type VI secretion system, biofilm formation and cell invasion in pathogen Pseudomonas plecoglossicida. Microbiol Res. 2023;266:127220.

5.Huang J, Yin X, Munang'andu HM, Xu C, Li W, Xie J, Yan X^#,Tao Z^#. Oral vaccination with feed-based live attenuated vaccine protects large yellow croaker against Pseudomonas plecoglossicida infection. Aquaculture. 2023;563:738932.

6.Yang Y, Wang G, Li Y, Hu J, Wang Y,Tao Z^#. Oocytes Skipped Spawning Through Atresia Is Regulated by Somatic Cells Revealed by Transcriptome Analysis in Pampus argenteus. Frontiers in Marine Science. 2022;9.

7.Li Y, Yan X,Tao Z^#. Two Type VI Secretion DNase Effectors are Utilized for Interbacterial Competition in the Fish Pathogen Pseudomonas plecoglossicida. Front Microbiol. 2022;13.

8.Ye H, Xu Z,Tao Z^#, Li W, Li Y, Yang A, Wang W, Yin X, Yan X^#. Efficacy and safety of Pseudomonas plecoglossicida mutant ΔtssD-1 as a live attenuated vaccine for the large yellow croaker (Larimichthys crocea). Aquaculture. 2021;531:735976.

9.Yang A, Li W,Tao Z^#, Ye H, Xu Z, Li Y, Gao Y, Yan X^#. Vibrio harveyi isolated from marine aquaculture species in eastern China and virulence to the large yellow croaker (Larimichthys crocea). J Appl Microbiol. 2021;131(4):1710-21.

10.Tao Z^#, Xu Y, Zhou S, Qian D, Liu M, Li W, Xu W, Yan X^#. Acquisition of a type VI secretion system is critical for Pseudomonas plecoglossicida induced granulomas in fish internal organs. Aquaculture. 2020;516:734629.

11.Tao Z, Shen C,Zhou S^#, Yang N, Wang G, Wang Y, Xu S. An outbreak of Photobacterium damselae subsp. damselae infection in cultured silver pomfret Pampus argenteus in Eastern China. Aquaculture. 2018;492:201-5.

12.Dai W, Yu W, Xuan L,Tao Z, Xiong J^#. Integrating molecular and ecological approaches to identify potential polymicrobial pathogens over a shrimp disease progression. Applied microbiology and biotechnology. 2018;102(8):3755-64.

13.Zhou S,Tao Z, Shen C, Qian D, Wang C, Zhou Q, Jin S. β-actin gene expression is variable among individuals and not suitable for normalizing mRNA levels in Portunus trituberculatus. Fish Shellfish Immunol. 2018;81:338-42.

14.Zhang H, Wang H, Zheng W, Yao Z, Peng Y, Zhang S, Hu Z,Tao Z^#, Zheng T^#. Toxic Effects of Prodigiosin Secreted by Hahella sp. KA22 on Harmful Alga Phaeocystis globosa. Front Microbiol. 2017;8(999).

15.Dai W, Yu W, Zhang J, Zhu J,Tao Z,Xiong J^#. The gut eukaryotic microbiota influences the growth performance among cohabitating shrimp. Applied microbiology and biotechnology. 2017;101(16):6447-57.

16.Yuan L, Li M^#, Zhang Y,Tao Z, Wang R^#. The protective effects of dietary zinc on dietary copper toxicity in large yellow croaker Larimichthys croceus. Aquaculture. 2016;462:30-4.

17.Yang N, Zhang D,Tao Z, Li M, Zhou S^#, Wang G^#. Identification of a novel class B scavenger receptor homologue in Portunus trituberculatus: molecular cloning and microbial ligand binding. Fish Shellfish Immunol. 2016;58:73-81.

18.Tao Z^#,Zhou T, Zhou S, Wang G. Temperature-regulated expression of type VI secretion systems in fish pathogen Pseudomonas plecoglossicida revealed by comparative secretome analysis. FEMS Microbiol Lett. 2016;363(22):fnw261.

19.Liu L, Ge M, Zheng X,Tao Z,Zhou S, Wang G^#. Investigation of Vibrio alginolyticus, V. harveyi, and V. parahaemolyticus in large yellow croaker, Pseudosciaena crocea (Richardson) reared in Xiangshan Bay, China. Aquaculture Reports. 2016;3:220-4.

20.Zhou S, Li M, Yang N, Liu S, Yuan X,Tao Z,Wang G^#. First description and expression analysis of tumor necrosis factor receptor-associated factor 6 (TRAF6) from the swimming crab, Portunus trituberculatus. Fish Shellfish Immunol. 2015;45(2):205-10.

21.Tao Z,Bullard SA, Arias CR^#. Diversity of Bacteria Cultured from the Blood of Lesser Electric Rays Caught in the Northern Gulf of Mexico. J Aquat Anim Health. 2014;26(4):225-32.

22.Larsen A,Tao Z, Bullard SA, Arias CR^#. Diversity of the skin microbiota of fishes: evidence for host species specificity. FEMS Microbiol Ecol. 2013;85(3):483-94.

23.Tao Z, Larsen AM, Bullard SA, Wright AC, Arias CR^#. Prevalence and population structure of Vibrio vulnificus on fishes from the northern Gulf of Mexico. Applied and environmental microbiology. 2012;78(21):7611-8.

24.Tao Z, Bullard S, Arias C^#. High numbers of Vibrio vulnificus in tar balls collected from oiled areas of the north-central Gulf of Mexico following the 2010 BP Deepwater Horizon oil spill. EcoHealth. 2011;8(4):507-11.

授权发明专利

1.陶震,钱冬,周素明,许文军.敲除T6SS-1基因簇的杀香鱼假单胞菌鱼用减毒疫苗. CN201910043819.9

学生培养工作

担任18养殖2班班主任， 指导的本科生共有27名，其中有23位同学考研，考研率达到85.16%，其中16位同学被成功录取，录取率为69.56%，录取单位包括中国科学院大学、宁波大学、上海海洋大学等高校。指导的研究生叶浩达获得校级优秀硕士学位论文（2021）、浙江优秀硕士学位论文（2021）和省级优秀毕业生的荣誉；研究生李彦彦获得校级优秀硕士学位论文（2022）。